To determine if the thymus is involved in the induction of tolerance in our two haplotype class i mismatched renal allograft model the effect of thymectomy 21 d before renal transplantation was examined the data from this study demonstrate that the thymus is essential for rapid and stable tolerance induction. This breaking of tolerance could only be seen in mice given additional thymocytes as the tolerance of the td cells was not broken in the absence of a thymus thus the induction of tolerance as well as the induction of immunity in thymus dependent bmd cell populations seems to require the co operation of td cells. This chapter discusses the role of accessory and thymus derived cells in resistance to tolerance induction in adult animals of some strains a considerable resistance to tolerance induction has been observed in an experiment discussed in the chapter in balb c mice this resistance is attributable to the aggregate content of antigens and the . Add tags for the role of the thymus in tolerance induction be the first similar items related subjects 7 immunological tolerance thymus physiology t cells differentiation immune tolerance t lymphocytes physiology thymus gland physiology thymus confirm this request
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