Note citations are based on reference standards however formatting rules can vary widely between applications and fields of interest or study the specific requirements or preferences of your reviewing publisher classroom teacher institution or organization should be applied. Streamlining molecular pathobiology of malignant melanoma involve recognition of cmm stem progenitor cells starting pierard ge pierard franchimont c humbert p delvenne p 2016 streamlining molecular pathobiology of malignant page 3 of 9 melanoma clin res dermatol open access 33 1 9. For 2010 68130 new cases of cutaneous malignant melanoma were estimated or 5 of all newly diagnosed cancers 4 although the incidence of malignant melanoma more than doubled between 1975 and 2000 new cases of melanoma are being diagnosed earlier in the course of the disease because of increased public awareness and the mortality rate has . Malignant melanoma is one of the most aggressive malignancies in human and is responsible for almost 60 of lethal skin tumors its incidence has been increasing in white population in the past two decades there is a complex interaction of environmental exogenous and endogenous including genetic risk factors in developing malignant melanoma 8 12 of familial melanomas occur in a . Melanoma is a malignant tumor of melanocytes neural crest derivatives that contain melanin producing organelles known as melanosomes melanocytes are normally found in the basal layer of the epidermis but are also found in the eye gallbladder anus and vagina and throughout the upper aerodigestive tract
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